Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Efficacy of Atorvastatin Plus Aspirin in Comparison with Atorvastatin Alone on Liver Function and Degree of Fibrosis in Patients with Cryptogenic Cirrhosis: A Randomized Double-Blind Clinical Trial

(2019) Efficacy of Atorvastatin Plus Aspirin in Comparison with Atorvastatin Alone on Liver Function and Degree of Fibrosis in Patients with Cryptogenic Cirrhosis: A Randomized Double-Blind Clinical Trial. Hepatitis Monthly. ISSN 1735-143X

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Official URL: https://sites.kowsarpub.com/hepatmon/articles/9234...

Abstract

Objectives: This study was conducted to evaluate the efficacy of a combination therapy using aspirin (also known as acetylsalicylic acid (ASA)) and atorvastatin in comparison with atorvastatin alone to improve liver fibrosis and function in patients with cryptogenic cirrhosis. Methods: In this randomized double-blinded clinical trail, 40 patients with cryptogenic cirrhosis were randomly allocated to the intervention group (atorvastatin +ASA) and the control group (atorvastatin) treated for six months. Then liver function and stiffness (based on transient electrography) were compared. A checklist was used for data collection and the results were analyzed by SPSS 24 using chi-square test and paired t-test at the 0.05 significance level. Results: A total of 33 cases, includingl6 patients in group A (atorvastatin + ASA) and 17 in group B (atorvastatin + placebo) with a mean age of 50.3 +/- 11.2 and 47.9 +/- 10.6 years and BMI of 30.7 +/- 4.2 and 30.8 +/- 3.1 in groups A and B, were studied, respectively. Twelve patients (75%) in group A and 14 cases (82%) in group B were male. Both groups were homogenized in terms of demographic information at baseline. A significant improvement in Child score (P= 0.001 and P= 0.002 for groups A and B, respectively) and liver stiffness (P \textless 0.0001 and P = 0.007 for groups A and B, respectively) were observed in both groups after the intervention, however there was no significant improvement in child score (P = 0.982) and liver stiffness (P = 0.611) in comparing both groups. Conclusions: Although atorvastatin is effective in improvement of liver fibrosis and function in cryptogenic cirrhosis, adding ASA cannot improve its effects.

Item Type: Article
Keywords: Aspirin, Atorvastatin , Liver Fibrosis , Cryptogenic Cirrhosis , Liver Stiffness
Subjects: WI Digestive System > WI 700-770 Liver. Biliary Tract
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Journal or Publication Title: Hepatitis Monthly
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 19
Number: 11
Publisher: ProQuest
Identification Number: https://doi.org/10.5812/hepatmon.92342
ISSN: 1735-143X
ISBN: 1735-143X
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5535

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