Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Prenatal exposure to diesel exhaust particles causes anxiety, spatial memory disorders with alters expression of hippocampal pro-inflammatory cytokines and NMDA receptor subunits in adult male mice offspring

(2019) Prenatal exposure to diesel exhaust particles causes anxiety, spatial memory disorders with alters expression of hippocampal pro-inflammatory cytokines and NMDA receptor subunits in adult male mice offspring. Ecotoxicol Environ Saf. pp. 34-41. ISSN Ecotoxicol Environ Saf

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Official URL: https://pubmed.ncbi.nlm.nih.gov/30921694/

Abstract

Air pollution by Diesel exhaust (DE) consists of gaseous compounds and diesel exhaust particles (DEPs). Previous studies show associations between prenatal exposure to diesel exhaust affects the central nervous system (CNS). However, there was not reported that these effects were caused by gaseous compounds, diesel exhaust particles, or both. A limited number of studies in rodent models have shown that exposure to DEPs can result in CNS. Here, we explored the effects of prenatal exposure to DEPs on anxiety and learning and memory in NMRI mice male offspring. Three groups of pregnant mice were exposed to 350-400mug DEPs/m(3) for 2, 4 and 6h daily in a closed system room. We examined anxiety and learning and memory in 8-to-9-week-old male offspring using the Elevated plus maze and Morris water maze (MWM) test. Hippocampi were isolated after the behavioral tests and measured pro-inflammatory cytokines and N-methyl-D-aspartate (NMDA) receptor expression by quantitative RT-PCR analysis. Mice exposed to DEPs in utero showed de fi cits in the Elevated plus maze and Morris water maze test. In addition, DEPs exposed mice exhibited decreased hippocampal NR2A and NR3B expression. Taken together, our data suggest that maternal DEP exposure is associated with anxiety, disrupts learning and memory and reduction hippocampal NR2A and NR3B expression in male offspring.

Item Type: Article
Keywords: *Prenatal Exposure Delayed Effects,Air Pollution/adverse effects/analysis,Animals,Anxiety/*chemically induced,Cytokines/metabolism,Diesel exhaust particles,Female,Hippocampus,Hippocampus/*drug effects/metabolism,Learning,Male,Memory,Memory Disorders/*chemically induced,Memory/*drug effects,Mice,NMDA receptor,Neuroin fl ammation,Pregnancy,Prenatal exposure,Receptors, N-Methyl-D-Aspartate/*metabolism,Vehicle Emissions/*toxicity
Subjects: WQ Obstetrics > WQ 215-270 Pregnancy Complications
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Occupational Health
Page Range: pp. 34-41
Journal or Publication Title: Ecotoxicol Environ Saf
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 176
Publisher: Elsevier
Identification Number: https://doi.org/10.1016/j.ecoenv.2019.03.090
ISSN: Ecotoxicol Environ Saf
ISBN: 0147-6513
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5437

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