Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Altered plasma visfatin levels and insulin resistance in patients with Alzheimer's disease

(2019) Altered plasma visfatin levels and insulin resistance in patients with Alzheimer's disease. Acta Neurol Belg. ISSN 0300-9009

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Official URL: https://pubmed.ncbi.nlm.nih.gov/30707409/

Abstract

Central insulin resistance is involved in the pathophysiology of Alzheimer's disease (AD). Visfatin (VIS), an adipokine secreted from peripheral adipose tissue, is involved in energy balance and weight control. Besides its metabolic roles, VIS possesses insulin-mimetic, anti-apoptotic, and neuroprotective properties. In this study, we assessed the presence of a correlation between plasma VIS level and insulin resistance or AD. Sixty participants were enrolled in this study; 34 patients with AD and 26 healthy subjects. All subjects underwent comprehensive evaluations including Mini-mental score exam (MMSE) for the diagnosis of dementia. Subjects with MMSE score \textless 24 were added to the AD group, while healthy subjects should have a MMSE score \textgreater 27. Fasting blood sugar (FBS) and insulin levels were measured by enzyme-linked immunosorbent assay. The results indicate a significant elevation in FBS from 103 +/- 3.0 to 147 +/- 7.6 in AD patients (p \textless/= 0.001). Additionally, 71% of AD patients developed insulin resistance, as the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index increased from 2.9 +/- 0.5 in healthy subjects to 5.2 +/- 0.7 in AD patients (p \textless/= 0.05). Body mass index and serum insulin level did not show a significant alteration, but serum VIS levels were significantly (p \textless/= 0.01) lower in AD patients (11.15 +/- 1.9 ng/ml) in comparison to control group (21.09 +/- 2.3 ng/ml). There is a negative correlation between plasma VIS level and the HOMA-IR index (p \textless 0.05). The results of this study present clear evidence for systemic insulin resistance and decreased serum VIS level in non-obese, non-overweight patients with moderate to severe AD.

Item Type: Article
Keywords: Alzheimer disease,Dementia,Insulin resistance,Visfatin
Subjects: WL Nervous System > WL 200-405 Central Nervous System. Disorders. Therapeutics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Neurology
Journal or Publication Title: Acta Neurol Belg
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Publisher: Springer
Identification Number: https://doi.org/10.1007/s13760-019-01084-9
ISSN: 0300-9009
ISBN: 0300-9009
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5422

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