Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

(2020) Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery. J Biomed Mater Res A. pp. 1688-1702. ISSN 1549-3296

Full text not available from this repository.

Official URL: https://pubmed.ncbi.nlm.nih.gov/32196926/

Abstract

The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.

Item Type: Article
Keywords: bovine serum albumin nanoparticles (BSANPs),drug release kinetic,microemulsion,multifunctional drug delivery,paclitaxel
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 1688-1702
Journal or Publication Title: J Biomed Mater Res A
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 108
Number: 8
Publisher: Wiley ,ProQuest
Identification Number: https://doi.org/10.1002/jbm.a.36935
ISSN: 1549-3296
ISBN: 1549-3296
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5421

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