Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats

(2016) Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats. Canadian Journal of Physiology and Pharmacology. pp. 669-675. ISSN 0008-4212

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Abstract

Long-term hyperglycemia associates with memory defects via hippocampal cells damaging. The aim of the present study was to examine the effect of 1 month of i.p. injections of AG on passive avoidance learning (PAL) and hippocampal apoptosis in rat. Eighty male rats were divided into 10 groups: control, nondiabetics and STZ-induced diabetics treated with AG (50, 100, 200, and 400 mg/kg, i.p.). PAL and the Bcl-2 family gene expressions were determined. Diabetes resulted in memory and Bcl-2 family gene expression deficits. AG (50 and 100 mg/kg) significantly improved the learning and Bcl-2, Bcl-xl, Bax, and Bak impairment in diabetic rats. However, negative effects were indicated by higher doses of the drug (200 and 400 mg/kg). Present study suggests that 1 month of i.p. injections of lower doses of AG, may improve the impaired cognitive tasks in STZ-induced diabetic rats possibly by modulating Bcl-2 family gene expressions.

Item Type: Article
Keywords: diabetes mellitus aminoguanidine passive avoidance learning Bcl-2 family genes rats NITRIC-OXIDE OXIDATIVE STRESS ENDOTHELIAL DYSFUNCTION LIPOPROTEIN OXIDATION COGNITIVE DYSFUNCTION CELL-DEATH APOPTOSIS SYSTEM MICE METHYLGLYOXAL Pharmacology & Pharmacy Physiology
Page Range: pp. 669-675
Journal or Publication Title: Canadian Journal of Physiology and Pharmacology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 94
Number: 6
Identification Number: https://doi.org/10.1139/cjpp-2015-0357
ISSN: 0008-4212
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/527

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