Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia

(2016) Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. Drug Development and Industrial Pharmacy. pp. 846-853. ISSN 0363-9045

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Abstract

Context: Flutamide is a potent anti-androgen with the several unwanted side effects in systemic administration, therefore, it has attracted special interest in the development of topically applied formulations for the treatment of androgenic alopecia. Objective: The purpose of this study was to prepare and characterize the solid lipid nanoparticles (SLNs) of Flutamide for follicular targeting in the treatment of the androgenic alopecia. Methods: Flutamide-loaded SLNs, promising drug carriers for topical application were prepared by hot melt homogenization method. Drug permeation and accumulation in the exercised rat skin and histological study on the male hamsters were performed to assess drug delivery efficiency in vitro and in vivo, respectively. Results: The optimized Flutamide-loaded SLNs (size 198 nm, encapsulation efficiency percentage 65 and loading efficiency percentage 3.27) exhibited a good stability during the period of at least 2 months. The results of X-ray diffraction showed Flutamide amorphous state confirming uniform drug dispersion in the SLNs structure. Higher skin drug deposition (1.75 times) of SLN formulation compared to Flutamide hydroalcoholic solution represented better localization of the drug in the skin. The in vivo studies showed more new hair follicle growth by utilizing Flutamide-loaded SLNs than Flutamide hydroalcoholic solution which could be due to the higher accumulation of SLNs in the hair follicles as well as slowly and continues release of the Flutamide through the SLNs maximizing hair follicle exposure by antiandrogenic drug. Conclusion: It was concluded Flutamide-loaded SLN formulation can be used as a promising colloidal drug carriers for topical administration of Flutamide in the treatment of androgenic alopecia.

Item Type: Article
Keywords: Androgenic alopecia solid lipid nanoparticle Flutamide transdermal drug delivery IN-VITRO DRUG-DELIVERY 5-ALPHA-REDUCTASE INHIBITORS PENETRATION ENHANCEMENT IDIOPATHIC HIRSUTISM TOPICAL DELIVERY SKIN PENETRATION FORMULATION SLN SURFACTANTS Chemistry, Medicinal Pharmacology & Pharmacy
Page Range: pp. 846-853
Journal or Publication Title: Drug Development and Industrial Pharmacy
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 42
Number: 6
Identification Number: https://doi.org/10.3109/03639045.2015.1062896
ISSN: 0363-9045
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/519

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