Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Diagnostic Investigations of DKK-1 and PDCD5 Expression Levels as Independent Prognostic Markers of Human Chondrosarcoma

(2016) Diagnostic Investigations of DKK-1 and PDCD5 Expression Levels as Independent Prognostic Markers of Human Chondrosarcoma. Iubmb Life. pp. 597-601. ISSN 1521-6543

Full text not available from this repository. (Request a copy)

Official URL: http://apps.webofknowledge.com/full_record.do?prod...

Abstract

In this study, we investigated the expression levels of Dickkopf-1 (DKK-1) and programmed cell death 5 (PDCD5) by using quantitative real-time PCR and immunohistochemistry in patients with chondrosarcoma. The DKK-1 mRNA levels were significantly higher in chondrosarcoma when compared with the corresponding nontumor tissues (mean +/- SD: 4.23 +/- 1.54; 1.54 +/- 0.87; P=0.001). PDCD5 mRNA levels were remarkably deceased in tumor tissues when compared with corresponding nontumor tissues (mean +/- SD: 1.94 +/- 0.73; 5.42 +/- 1.73; P=0.001). The high and moderate DKK-1 expressions were observed for 60 of chondrosarcoma samples in comparison with 27.5 of corresponding nontumor tissues (P = 0.001). Moreover, low expression of PDCD5 was found in 67.5 of the tumor tissues when compared with the nontumor tissues (32.5; P=0.002). The results of this study showed that high DKK-1 expression levels were strongly related to MSTS stage (P=0.011) and the advancement of histological grade (P<0.001). Furthermore, the PDCD5 expression levels were correlated with histological grade (P<0.001), MSTS stage (P=0.016), and distant metastasis (P=0.001). Kaplan-Meier survival and log-rank survival showed that patients with high DKK-1 levels and low PDCD5 levels were correlated with shorter overall survival (log-rank test P<0.001). PDCD5 levels, histological grade, and tumor stage were independent predictors of overall survival. In conclusion, DKK-1 and PDCD5 can be independent predictors of overall survival in patients suffering from chondrosarcoma. (C) 2016 IUBMB Life

Item Type: Article
Keywords: DKK-1 and PDCD5 chondrosarcoma immunohistochemistry patients PCR CELL-DEATH 5 REDUCED EXPRESSION PROSTATE-CANCER BREAST-CANCER DICKKOPF-1 GENE OSTEOSARCOMA ANTAGONIST APOPTOSIS TUMORS Biochemistry & Molecular Biology Cell Biology
Page Range: pp. 597-601
Journal or Publication Title: Iubmb Life
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 68
Number: 7
Identification Number: https://doi.org/10.1002/iub.1519
ISSN: 1521-6543
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/516

Actions (login required)

View Item View Item