Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV

(2016) No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV. Iranian Journal of Public Health. pp. 935-940. ISSN 2251-6085

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Abstract

Background: Kaposi's sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi's sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi's sarcoma in Tehran, Iran. Methods: We conducted a cross sectional survey on 99 patients with HIV infection referred to Iranian Research Center for HIV/AIDS and 40 healthy controls in Tehran, Iran from January to April 2014. The presence of HHV-8 DNA was detected in buffy coat samples of enrolled subjects using nested PCR assay. Results: A total of 99 HIV infected patients with mean age of 37.9 +/- 10 yr and 40 healthy controls with mean age of 39 +/- 11.5 yr were enrolled in the study. The mean CD4 count was 410.3 +/- 211.4 cells/mm(3). HHV-8 DNA was not detected in both healthy control and HIV patient groups. Conclusion: This survey showed low rate of HHV-8 DNA in healthy controls and HIV patients. Considering our findings HHV-8 infection does not seem to be widespread in our population. Further studies focusing on different regions of Iran appear to be required to have a more accurate estimation.

Item Type: Article
Keywords: Human immunodeficiency virus (HIV) Human herpesvirus 8 (HHV-8) Prevalence Viremia Iran SARCOMA-ASSOCIATED HERPESVIRUS HUMAN-IMMUNODEFICIENCY-VIRUS KAPOSIS-SARCOMA BLOOD-DONORS DNA-SEQUENCES ANTIRETROVIRAL THERAPY HHV-8 INFECTION SEROPREVALENCE AIDS TRANSMISSION Public, Environmental & Occupational Health
Page Range: pp. 935-940
Journal or Publication Title: Iranian Journal of Public Health
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 45
Number: 7
ISSN: 2251-6085
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/512

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