Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Gentamicin-gold nanoparticles conjugate: a contrast agent for X-ray imaging of infectious foci due to Staphylococcus aureus

(2016) Gentamicin-gold nanoparticles conjugate: a contrast agent for X-ray imaging of infectious foci due to Staphylococcus aureus. Iet Nanobiotechnology. pp. 190-194. ISSN 1751-8741

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Abstract

There is no optimal imaging method for the detection of unknown infectious foci in some diseases. This study introduces a novel method in X-ray imaging of infection foci due to Staphylococcus aureus by developing a contrast agent based on gold nanoparticles (GNPs). GNPs in spherical shape were synthesised by the reduction of tetrachloroauric acid with sodium citrate. Then gentamicin was bound directly to citrate functionalised GNPs and the complex was stabilised by polyethylene glycol. The interaction of gentamicin with GNPs was confirmed by ultraviolet-visible and Fourier transform infrared spectroscopies. The stability of complex was studied in human blood up to 6 h. The stability of conjugate was found to be high in human blood with no aggregation. The biodistribution study showed localisation of gentamicin-GNPs conjugate at the site of Staphylococcal infection. The infection site was properly visualised in X-ray images in mouse model using the gentamicin-GNPs conjugate as a contrast agent. The results demonstrated that one may consider the potential of new nanodrug as a contrast agent for X-ray imaging of infection foci in human beings which needs more investigations.

Item Type: Article
Keywords: drugs nanomedicine nanoparticles nanofabrication diagnostic radiography microorganisms diseases polymers ultraviolet spectra visible spectra Fourier transform infrared spectra gold gentamicin-gold nanoparticle conjugate contrast agent X-ray imaging Staphylococcus aureus disease tetrachloroauric acid reduction sodium citrate polyethylene glycol ultraviolet-visible spectroscopy Fourier transform infrared spectroscopy human blood Staphylococcal infection X-ray images murine model nanodrug ENHANCED PERMEABILITY ANTIBIOTICS VANCOMYCIN BACTERIA SPECTRA Biochemical Research Methods Nanoscience & Nanotechnology
Page Range: pp. 190-194
Journal or Publication Title: Iet Nanobiotechnology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 10
Number: 4
Identification Number: https://doi.org/10.1049/iet-nbt.2015.0034
ISSN: 1751-8741
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/507

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