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دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

(2016) Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats. Physiology & Behavior. pp. 177-183. ISSN 0031-9384

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Abstract

Early life stressful events have detrimental effects on the brain and behavior, which are associated with the development of depression. Immune-inflammatory responses have been reported to contribute in the pathophysiology of depression. Many studies have reported on the beneficial effects of exercise against stress. However, underlying mechanisms through which exercise exerts its effects were poorly studied. Therefore, it applied maternal separation (MS), as a valid animal model of early-life adversity, in rats from postnatal day (PND) 2 to 14 for 180 min per day. At PND 28, male Wistar albino rats were subjected to 5 experimental groups; 1) controls 2) MS rats 3) MS rats treated with fluoxetine 5 mg/kg to PND 60, 4) MS rats that were subjected to voluntary running wheel (RW) exercise and 5) MS rats that were subjected to mandatory treadmill (TM) exercise until adulthood. At PND 60, depressive-like behaviors were assessed by using forced swimming test (FST), splash test, and sucrose preference test (SPT). Our results revealed that depressive-like behaviors following MS stress were associated with an increase in expression of toll-like receptor 4 (Tlr-4) and its main signaling protein, Myd88, in the hippocampal formation. Also, we found that voluntary (and not mandatory) physical exercise during adolescence is protected against depressant effects of early-life stress at least partly through mitigating the innate immune responses in the hippocampus. (C) 2016 Published by Elsevier Inc.

Item Type: Article
Keywords: Maternal separation Depressive-like behaviors Toll-like receptors Voluntary exercise Mandatory exercise Hippocampus ENVIRONMENTAL ENRICHMENT MEMORY IMPAIRMENT SOCIAL-ISOLATION NITRIC-OXIDE GUT-BRAIN MALE-MICE ANXIETY MODEL INFLAMMATION PATHWAY Psychology, Biological Behavioral Sciences
Page Range: pp. 177-183
Journal or Publication Title: Physiology & Behavior
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 163
Identification Number: https://doi.org/10.1016/j.physbeh.2016.05.017
ISSN: 0031-9384
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/501

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