Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Morphine Attenuated the Cytotoxicity Induced by Arsenic Trioxide in H9c2 Cardiomyocytes

(2016) Morphine Attenuated the Cytotoxicity Induced by Arsenic Trioxide in H9c2 Cardiomyocytes. Biological Trace Element Research. pp. 132-139. ISSN 0163-4984

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Abstract

Arsenic trioxide (ATO) is an efficient drug for the treatment of the patients with acute promyelocytic leukemia (APL). Inhibition of proliferation as well as apoptosis, attenuation of migration, and induction of differentiation in tumor cells are the main mechanisms through which ATO acts against APL. Despite advantages of ATO in treatment of some malignancies, certain harmful side effects, such as cardiotoxicity, have been reported. It has been well documented that morphine has antioxidant, anti-apoptotic, and cytoprotective properties and is able to attenuate cytotoxicity. Therefore, in this study, we aimed to investigate the protective effects of morphine against ATO toxicity in H9c2 myocytes using multi-parametric assay including thiazolyl blue tetrazolium bromide (MTT) assay, reactive oxygen species (ROS) generation, caspase 3 activity, nuclear factor kappa B (NF-kappa B) phosphorylation assay, and expression of apoptotic markers. Our results showed that morphine (1 mu M) attenuated cytotoxicity induced by ATO in H9c2 cells. Results of this study suggest that morphine may have protective properties in management of cardiac toxicity in patients who receive ATO as an anti-cancer treatment.

Item Type: Article
Keywords: Arsenic trioxide Morphine Cardiomyocyte Cytotoxicity H9c2 ACUTE PROMYELOCYTIC LEUKEMIA NF-KAPPA-B RAT-LIVER MITOCHONDRIA OXIDATIVE STRESS CELL-DEATH IN-VITRO APOPTOSIS CANCER TOXICITY ACTIVATION Biochemistry & Molecular Biology Endocrinology & Metabolism
Page Range: pp. 132-139
Journal or Publication Title: Biological Trace Element Research
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 173
Number: 1
Identification Number: https://doi.org/10.1007/s12011-016-0631-5
ISSN: 0163-4984
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/500

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