Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Plasma homocysteine levels, methylene tetrahydrofolate reductase A1298C gene polymorphism and risk of retinal vein thrombosis

(2016) Plasma homocysteine levels, methylene tetrahydrofolate reductase A1298C gene polymorphism and risk of retinal vein thrombosis. Blood Coagulation & Fibrinolysis. pp. 679-683. ISSN 0957-5235

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Abstract

There are limited data regarding the role of methylene tetrahydrofolate reductase (MTHFR) A1298C polymorphism and hyperhomocysteinemia as risk factors for retinal vein thrombosis (RVT) in Iranians. This study aimed to examine a possible association between fasting plasma total homocysteine (tHcy) levels, MTHFR A1298C polymorphism and RVT development in Iranian patients. Our study population consisted of 73 patients with a diagnosis of RVT (52.7 +/- 16.2 years) and 73 age and sex-matched healthy controls (49.1 +/- 14.6 years). Genotyping for the MTHFR A1298Cpolymorphism was conducted by PCR-RFLP technique and plasma tHcy levels were measured by an enzyme immunoassay method. Fasting plasma tHcy levels were 20.29 +/- 8.5 mu mol/l in RVT patients and 10.9 +/- 3.1 mu mol/l in control subjects. The number of cases with abnormal tHcy values (hyperhomocysteinemia) was significantly higher in the RVT patients than control subjects (P=0.0001). The prevalence of MTHFR 1298CC homozygote genotype was similar in RVT patients and controls (17.8 vs. 15.1, P=0.45). There were no significant differences in genotype distribution of MTHFR A1298C polymorphism between males and females in both RVT patients and controls (P>0.05). The frequency of the 1298C allele was 39.1 and 35.6 in patients and controls, respectively, and did not differ significantly between them (P=0.23). Moreover, heterozygote and homozygote genotypes in the RVT patients had significantly higher abnormal tHcy values than corresponding genotypes in control subjects (P<0.001). Our study demonstrated that hyperhomocysteinemia but not homozygosity for MTHFR A1298C polymorphism is a significant risk factor for RVT in the Iranian population. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Keywords: A1298C polymorphism homocysteine methylenetetrahydrofolatereductase polymerase chain reaction-restriction fragment length polymorphism retinal vein thrombosis MTHFR C677T MUTATION METHYLENETETRAHYDROFOLATE REDUCTASE ELEVATED HOMOCYSTEINE ARTERY-OCCLUSION HYPERHOMOCYSTEINEMIA DISEASE METAANALYSIS ASSOCIATION GENOTYPE POPULATION Hematology
Page Range: pp. 679-683
Journal or Publication Title: Blood Coagulation & Fibrinolysis
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 27
Number: 6
Identification Number: https://doi.org/10.1097/mbc.0000000000000476
ISSN: 0957-5235
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/499

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