Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

The molecular signature of breast cancer metastasis to bone

(2016) The molecular signature of breast cancer metastasis to bone. Anti-Cancer Drugs. pp. 824-831. ISSN 0959-4973

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Official URL: <Go to ISI>://WOS:000384001000003

Abstract

Distant metastasis during the advanced stage of malignant tumor progression can cause considerable morbidity in cancer patients. Bone is known to be one of the most common sites of distant metastasis in patients with breast cancer (BC). BC metastases in bone are associated with excessive skeletal complications. These complications can be fatal and reduce quality of life of patients. It is important to understand the metastatic process of BC to bone to improve quality of life and design new therapeutic methods. At present, the molecular mechanisms leading to the BC metastasis to bone are not fully understood. Studying the molecular basis of BC metastasis to bone might improve our insight into this complex process. In addition, it can provide novel approaches for designing advanced and effective targeted therapies. The present article aimed to review the published papers on the molecular basis of the metastatic process of BC to bone, focusing on involved genes and signaling networks. Furthermore, we propose potential therapeutic targets that may be more effective for the inhibition and treatment of BC metastasis to bone.

Item Type: Article
Keywords: bone metastasis breast cancer metastasis genes and signaling network targeted therapy EPITHELIAL-MESENCHYMAL TRANSITION GROWTH-FACTOR-BETA CHEMOKINE RECEPTOR CXCR4 KINASE C-SRC STEM-CELLS THERAPEUTIC OPPORTUNITIES IN-VIVO MATRIX METALLOPROTEINASES SIGNALING PATHWAY MULTIPLE-MYELOMA Oncology Pharmacology & Pharmacy
Page Range: pp. 824-831
Journal or Publication Title: Anti-Cancer Drugs
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 27
Number: 9
Identification Number: https://doi.org/10.1097/cad.0000000000000401
ISSN: 0959-4973
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/484

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