Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Occult hepatitis B virus infection and S gene escape mutants in HIV-infected patients after hepatitis B virus vaccination

(2016) Occult hepatitis B virus infection and S gene escape mutants in HIV-infected patients after hepatitis B virus vaccination. International Journal of Std & Aids. pp. 967-972. ISSN 0956-4624

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Abstract

Hepatitis B virus (HBV) vaccination is recommended for HIV patients. Despite the relative success of HBV vaccination, breakthrough infections can occur infrequently in patients, and it can be due to occult HBV infection, vaccine unresponsiveness and/or emergence of escape mutants. This study assessed the presence of occult HBV infection and S gene escape mutants in HIV-positive patients after HBV vaccination. Ninety-two HIV-positive patients were enrolled in this study, including 52 responders to HBV vaccine and 40 non-responders. All of the cases received HBV vaccine according to routine HBV vaccination protocols. The presence of HBV-DNA was determined by real-time polymerase chain reaction (PCR). In HBV-DNA positive samples, the most conserved regions of S gene sequences were amplified by nested PCR and PCR products were sequenced. Occult HBV infection was detected in two cases. Glycine to arginine mutation at residue 145 (G145R) within the a' region of the S gene was detected in one of the occult HBV infection cases who was in the non-responder group. This study showed that the prevalence of occult HBV infection and vaccine escape mutants was low in our HBV-vaccinated HIV-positive patients in both responder and non-responder groups, so there was no alarming evidence indicating breakthrough HBV infection in our vaccinated HIV-positive cases.

Item Type: Article
Keywords: Human immunodeficiency virus HIV AIDS hepatitis B virus occult hepatitis B virus infection S gene mutation vaccination HUMAN-IMMUNODEFICIENCY-VIRUS SURFACE-ANTIGEN VIRAL-HEPATITIS PUBLIC-HEALTH HBV MUTANTS CHILDREN TAIWAN SEROPREVALENCE COINFECTION MUTATIONS Immunology Infectious Diseases
Page Range: pp. 967-972
Journal or Publication Title: International Journal of Std & Aids
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 27
Number: 11
Identification Number: https://doi.org/10.1177/0956462415602419 http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=13&SID=F1L5Ac7B67nL9Ssx4CL&page=1&doc=1
ISSN: 0956-4624
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/482

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