Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Preparation and in vitro/pharmacokinetic/pharmacodynamic evaluation of a slow-release nano-liposomal form of prednisolone

(2016) Preparation and in vitro/pharmacokinetic/pharmacodynamic evaluation of a slow-release nano-liposomal form of prednisolone. Drug Delivery. pp. 3008-3016. ISSN 1071-7544

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Official URL: <Go to ISI>://WOS:000388750400041

Abstract

A nano-liposomal carrier was prepared for the anti-inflammatory drug prednisolone acetate (PA). The drug showed remarkable loading in the nano-carriers. The drug-loaded nano-liposmes with average sizes of about 186nm and zeta potentials of - 20mV were obtained. Our drug release studies showed an apparently zero-order trend with only 18 of the drug released in the first 120 h. Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) analyses showed no chemical interaction between the drug and carrier. Transmission electron microscopy (TEM) imaging showed near-spherical drug-containing nanocarriers. The intramuscular (IM) trial of the nanoformulation compared with the free drug showed both pharmacokinetic (lower C-max, higher area under the curve (AUC)) and pharmacodynamic (higher and longer lasting anti-inflammatory effect, both macroscopically and biochemically) superiority for the nano-liposomal drug above the free prednisolone in rats.

Item Type: Article
Keywords: Nano-liposomes pharmacodynamic evaluation pharmacokinetic evaluation prednisolone slow-release DRUG-DELIVERY SYSTEMS ENCAPSULATED PREDNISOLONE EXPERIMENTAL ARTHRITIS GLUCOCORTICOIDS PHOSPHATE MICE CHROMATOGRAPHY MACROPHAGES CANCER MODEL Pharmacology & Pharmacy
Page Range: pp. 3008-3016
Journal or Publication Title: Drug Delivery
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 23
Number: 8
Identification Number: https://doi.org/10.3109/10717544.2016.1138341
ISSN: 1071-7544
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/478

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