(2016) Preparation and in vitro/pharmacokinetic/pharmacodynamic evaluation of a slow-release nano-liposomal form of prednisolone. Drug Delivery. pp. 3008-3016. ISSN 1071-7544
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Abstract
A nano-liposomal carrier was prepared for the anti-inflammatory drug prednisolone acetate (PA). The drug showed remarkable loading in the nano-carriers. The drug-loaded nano-liposmes with average sizes of about 186nm and zeta potentials of - 20mV were obtained. Our drug release studies showed an apparently zero-order trend with only 18 of the drug released in the first 120 h. Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) analyses showed no chemical interaction between the drug and carrier. Transmission electron microscopy (TEM) imaging showed near-spherical drug-containing nanocarriers. The intramuscular (IM) trial of the nanoformulation compared with the free drug showed both pharmacokinetic (lower C-max, higher area under the curve (AUC)) and pharmacodynamic (higher and longer lasting anti-inflammatory effect, both macroscopically and biochemically) superiority for the nano-liposomal drug above the free prednisolone in rats.
| Item Type: | Article |
|---|---|
| Keywords: | Nano-liposomes pharmacodynamic evaluation pharmacokinetic evaluation prednisolone slow-release DRUG-DELIVERY SYSTEMS ENCAPSULATED PREDNISOLONE EXPERIMENTAL ARTHRITIS GLUCOCORTICOIDS PHOSPHATE MICE CHROMATOGRAPHY MACROPHAGES CANCER MODEL Pharmacology & Pharmacy |
| Page Range: | pp. 3008-3016 |
| Journal or Publication Title: | Drug Delivery |
| Abstract and Indexing: | ISI, Pubmed, Scopus |
| Quartile : | Q2 |
| Volume: | 23 |
| Number: | 8 |
| Identification Number: | https://doi.org/10.3109/10717544.2016.1138341 |
| ISSN: | 1071-7544 |
| Depositing User: | خانم مریم زرقانی |
| URI: | http://repository.zums.ac.ir/id/eprint/478 |
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