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دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn's Disease

(2017) Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn's Disease. Neuroscience. pp. 124-137. ISSN 0306-4522

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Abstract

Depression and anxiety are common comorbid disorders observed in patients with inflammatory bowel disease (IBD). Increasing line of evidence indicates that immune-inflammatory responses are involved in co-occurrence of mood disorders and IBD. However, the mechanisms through which immune-inflammatory pathways modulate this comorbidity are not yet understood. This study investigated the role of innate immunity in the development of behavioral abnormalities associated with an animal model of Crohn's disease (CD). To do this, we induced colitis in male adult mice by intrarectal (i.r.) injection of DNBS (Dinitrobenzene sulfonic acid). After 3 days, we performed behavioral tests for anxiety- and depressive-like behaviors as well as tissue collection. Our results showed that DNBS-induced colonic inflammatory responses were accompanied by infiltration of inflammatory cells, and increased expression of genes involved in toll-like receptor signaling pathway in intestinal tissue. Furthermore, the DNBS-treated mice showed depressive- and anxiety-like behaviors which were associated with increased expression of the inflammatory genes and abnormal mitochondrial function in the hippocampus. These results suggest that peripheral inflammation is able to increase the transcriptional level of the genes in toll-like receptor pathway, induces abnormal mitochondrial function in the hippocampus, and these negative effects may be involved in the co-occurrence of anxiety and depression in early stages of CD. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: toll-like receptor pathway hippocampus oxidative stress Crohn's disease anxiety depression TOLL-LIKE-RECEPTOR NITROSATIVE STRESS PATHWAYS INDUCED OXIDATIVE STRESS TAIL SUSPENSION TEST BRAIN-GUT AXIS BOWEL-DISEASE MITOCHONDRIAL DYSFUNCTION SOCIAL-ISOLATION NITRIC-OXIDE RAT MODEL Neurosciences
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 124-137
Journal or Publication Title: Neuroscience
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 366
Identification Number: https://doi.org/10.1016/j.neuroscience.2017.10.023 <Go to ISI>://WOS:000415967300013
ISSN: 0306-4522
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/453

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