Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Is α-N-acetylgalactosaminidase the key to curing cancer? A mini-review and hypothesis

(2017) Is α-N-acetylgalactosaminidase the key to curing cancer? A mini-review and hypothesis. Journal of B.U.ON.. pp. 1372-1377. ISSN 11070625 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In the constant battle against cancer cells, macrophages are of great importance. Their activation is achieved through various mechanisms such as Vitamin D binding protein (VDBP or Gc). After undergoing modifications via enzymes secreted by stimulated lymphocytes, VDBP is modified into Macrophages Activator Form/Factor (Gc-MAF). Some studies (particularly those focusing on cancer) have reported that an enzyme known as α-N-acetylgalactosaminidase (nagalase) facilitates the deglycosylation of Gc-MAF, which in turn inhibits the activation of macrophages. The aim of this review was to evaluate studies associated with nagalase and its escalation in various diseases and to propose hypothetical solutions in order to neutralize the effects of nagalase in cancer patients. © 2017 Zerbinis Publications. All rights reserved.

Item Type: Article
Keywords: Macrophages activator factor Neoplasms Vitamin D binding protein Α-N-acetylgalactosaminidase alpha n acetylgalactosaminidase macrophage activating factor monoclonal antibody tumor marker cancer cell cancer cell line cancer patient cancer prognosis cancer therapy correlation analysis deglycosylation enzyme activity enzyme inhibition enzyme release evaluation study gene silencing human lymphocyte macrophage macrophage activation metastasis microorganism nonhuman protein blood level protein expression protein structure Review
Page Range: pp. 1372-1377
Journal or Publication Title: Journal of B.U.ON.
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 22
Number: 6
Identification Number: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=118&SID=C48LsSa76YoWspN8AAK&page=1&doc=1
ISSN: 11070625 (ISSN)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/366

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