Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study

(2017) Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study. Environmental Toxicology. pp. 2191-2202. ISSN 1522-7278 (Electronic) 1520-4081 (Linking)

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Abstract

Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect of ziziphora tenuior extract in 3 different doses (40, 80, 160 mg/kg) was determined. We administrated maximum tolerated dose of CPF (6.75 mg/kg) by gavage for 8 weeks (5 times in week) to male rats. Rats were sacrificed 24 h after last dose and the biochemical analysis, which confirms involvement of oxidative stress in the pathogenesis of CPF toxicity in liver including increased in lipid peroxidation, protein carbonyl content, and ROS formation, glutathione depletion, decreased of antioxidant effect via frap oxidation and cytochrome c expulsion. In addition, pathological lesions confirm the dysfunction of the organs (liver and lung). In addition, using of ziziphora extract as an antioxidant is resulted in amelioration of oxidative stress marker in liver and lung damage. In conclusion, the current study revealed that CPF toxicity is related to oxidative stress and induction of cell death signaling and cotreatment with ziziphora extract is recommended in the routine therapy for the protection against CPF induced liver and lung tissue damage.

Item Type: Article
Keywords: Animals Antioxidants/*pharmacology Chlorpyrifos/*toxicity Glutathione/metabolism Insecticides/*toxicity Lamiaceae/*chemistry Lipid Peroxidation/drug effects Liver/drug effects/metabolism Lung/drug effects/metabolism Male Oxidative Stress/drug effects Plant Extracts/*pharmacology Protein Carbonylation Rats, Sprague-Dawley Toxicity Tests, Subchronic chlorpyrifos (CPF) liver lung oxidative stress ziziphora extract
Page Range: pp. 2191-2202
Journal or Publication Title: Environmental Toxicology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 32
Number: 9
Identification Number: https://doi.org/10.1002/tox.22432 http://www.ncbi.nlm.nih.gov/pubmed/28569040
ISSN: 1522-7278 (Electronic) 1520-4081 (Linking)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/311

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