Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Preparation and in vivo evaluation of anti-plasmodial properties of artemisinin-loaded PCL-PEG-PCL nanoparticles

(2018) Preparation and in vivo evaluation of anti-plasmodial properties of artemisinin-loaded PCL-PEG-PCL nanoparticles. Pharm Dev Technol. pp. 911-920.

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Abstract

PURPOSE: Artemisinin (ART) has anti-inflammatory, antimicrobial, antioxidant, anti-amyloid, and anti-malarial effects, but its application is limited due to its low water solubility and poor oral bioavailability. In this study, the bioavailability, water solubility, and anti-plasmodial property of ART were improved by PCL-PEG-PCL tri-block copolymers. METHODS: The structure of the copolymers was characterized by (1)H NMR, FT-IR, DSC, and GPC techniques. ART was encapsulated within micelles by a single-step nano-precipitation method, leading to the formation of ART-loaded PCL-PEG-PCL micelles. The obtained micelles were characterized by dynamic light scattering (DLS) and atomic force microscopy (AFM). The in vivo anti-plasmodial activity of ART-loaded micelles was measured against Plasmodium berghei infected Swiss albino mice. RESULTS: The results showed that the zeta potential of ART-loaded micelles was about -8.37 mV and the average size was 91.87 nm. ART was encapsulated into PCL-PEG-PCL micelles with a loading capacity of 19.33 +/- 0.015% and encapsulation efficacy of 87.21 +/- 3.32%. In vivo anti-plasmodial results against P. berghei showed that multiple injections of ART-loaded micelles could prolong the circulation time and increase the therapeutic efficacy of ART. CONCLUSION: These results suggested that PCL-PEG-PCL micelles would be a potential carrier for ART for the treatment of malaria.

Item Type: Article
Keywords: Animals,Anti-Infective Agents/*administration & dosage/chemical,Artemisinin,Artemisinins/chemical synthesis/pharmacokinetics,Drug Carriers/*administration & dosage/chemical synthesis/pharmacokinetics,Drug Evaluation, Preclinical/methods,Female,Malaria/*drug therapy/metabolism,Mice,Nanoparticles/*administration & dosage/chemistry/metabolism,Pcl-peg-pcl,Plasmodium berghei,Plasmodium berghei/*drug effects/physiology,Polyesters/*administration & dosage/chemical synthesis/pharmacokinetics,Polyethylene Glycols/*administration & dosage/chemical synthesis/pharmacokinetics,drug delivery,micelles,synthesis/pharmacokinetics
Page Range: pp. 911-920
Journal or Publication Title: Pharm Dev Technol
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 23
Number: 9
Identification Number: https://doi.org/10.1080/10837450.2017.1372781
ISBN: 1083-7450
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/3105

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