Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Hepatitis A infection in patients with chronic viral liver disease: a cross-sectional study in Jahrom, Iran

(2015) Hepatitis A infection in patients with chronic viral liver disease: a cross-sectional study in Jahrom, Iran. EPIDEMIOLOGY AND INFECTION. pp. 534-539.

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Abstract

Infection with hepatitis A virus (HAV) in patient with chronic liver disease (CLD; due to hepatitis B or hepatitis C) may cause severe disease and fulminant liver failure. This study aimed to determine the seroprevalence of HAV antibodies in patients infected with HCV or HBV in Iran (Jahrom city). A total of 159 patients with underlying CLD were recruited between September 2012 and February 2013. Serum samples were collected from each patient and tested for anti-HAV using enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence of total anti-HAV was 79.2%. Patients aged 20-30 years had the lowest (28.3%) anti-HAV seropositivity and those aged >50 years had the highest (95%) seropositivity. The overall prevalence of anti-HAV in patients with chronic HCV and HBV infection was 93.7% and 77.1%, respectively. The anti-HAV seropositivity in liver cirrhosis patients was 100% compared to CLD patients. Because of low HAV immunity in younger CLD patients, vaccination against HAV should be considered.

Item Type: Article
Keywords: ELISA; hepatitis A; hepatitis B; hepatitis C
Page Range: pp. 534-539
Journal or Publication Title: EPIDEMIOLOGY AND INFECTION
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 143
Number: 3
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2913

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