Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population

(2017) Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population. Birth Defects Research. pp. 1386-1389. ISSN 2472-1727 (Electronic)

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Abstract

BACKGROUND: The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. METHODS: In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant. RESULTS: For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0.810) and control group (p = 0.422) were in Hardy-Weinberg equilibrium. There was no statistically significant difference in the genotype distribution (p = 0.059) and allele frequency (p = 0.065) of the TGFA TaqI polymorphism in the NSCLP and control groups. CONCLUSION: TGFA TaqI polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386-1389, 2017.(c) 2017 Wiley Periodicals, Inc.

Item Type: Article
Keywords: Adolescent Adult Case-Control Studies Child Child, Preschool Cleft Lip/*genetics Cleft Palate/*genetics Deoxyribonucleases, Type II Site-Specific/*metabolism Female Gene Frequency *Genetic Association Studies *Genetic Predisposition to Disease Humans Infant Infant, Newborn Iran Male *Polymorphism, Genetic Polymorphism, Restriction Fragment Length/genetics Risk Factors Transforming Growth Factor alpha/*genetics Young Adult association study cleft lip cleft palate polymorphism transforming growth factor alpha
Page Range: pp. 1386-1389
Journal or Publication Title: Birth Defects Research
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 109
Number: 17
Identification Number: https://doi.org/10.1002/bdr2.1125 http://www.ncbi.nlm.nih.gov/pubmed/29105380
ISSN: 2472-1727 (Electronic)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/290

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