Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Toxicity Mechanisms of Cigarette Smoke on Mouse Fetus Mitochondria

(2015) Toxicity Mechanisms of Cigarette Smoke on Mouse Fetus Mitochondria. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH. pp. 131-138.

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Maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. Unfortunately, there is an increasing interest within public especially woman in Iran in the tobacco products consumption. On the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encouraged us to investigate toxicity mechanisms of cigarette smoke on mouse fetus mitochondria. For this purpose different concentrations (1, 10 and 100%) of standardized cigarette smoke extract (CSE) were administrated on mitochondria isolated from fetus of NMRI mice on the 15 day of gestation. Our results showed a significant increase in ROS (Reactive oxygen species) formation, lipid peroxidation, mitochondrial membrane potential collapse, mitochondrial swelling and finally a decrease in ATP concentration in the CSE-treated isolated fetus mitochondria. Our results suggest that CSE-induced embryo toxicity is the result of disruptive effect on mitochondrial respiratory chain that leads to ROS formation, lipid peroxidation, mitochondrial MMP (mitochondrial membrane potential) decline and decrease of ATP level which starts apoptosis signaling.

Item Type: Article
Keywords: Cigarette smoke extract (CSE); Embryo toxicity; Mouse fetus; Isolated mitochondria
Page Range: pp. 131-138
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 14
Number: S
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی

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