Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Determination of Mycophenolic Acid in Plasma Samples Using the Terbium-Sensitized Luminescence Method

(2015) Determination of Mycophenolic Acid in Plasma Samples Using the Terbium-Sensitized Luminescence Method. JOURNAL OF APPLIED SPECTROSCOPY. pp. 614-619.

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Abstract

The objectives of this work were to provide an analytical method, for the quantitative determination of the mycophenolic acid (MFA) in plasma samples and its application to quantification of the MFA in rat plasma after oral administration. In order to remove the fluorescence interferences of the plasma, the samples were precipitated by acetonitrile in 1:8 ratio and then a few parameters were optimized and the fluorescence intensity measured at 545 nm using an excitation wavelength of 347 nm. Under the optimized concentration, the method provided a linear range between 1.0 and 10.0 mg/l with a correlation coefficient of 0.998. MFA was detected and the validation was performed according to the FDA guidelines. Linearity, accuracy, precision, and selectivity of the developed method were suitable for th determination of the MFA in plasma samples. The proposed analytical approach was applied to determine the MFA concentration in D degrees rat plasma-time profile study.

Item Type: Article
Keywords: mycophenolic acid; spectrofluorimetry; plasma; sensitized luminescence; MFA concentration-time profile
Page Range: pp. 614-619
Journal or Publication Title: JOURNAL OF APPLIED SPECTROSCOPY
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 82
Number: 4
Publisher: web of science
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2608

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