Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Core-shell fibrous scaffold as a vehicle for sustained release of retinal pigmented epithelium-derived factor (PEDF) for photoreceptor differentiation of conjunctiva mesenchymal stem cells

(2017) Core-shell fibrous scaffold as a vehicle for sustained release of retinal pigmented epithelium-derived factor (PEDF) for photoreceptor differentiation of conjunctiva mesenchymal stem cells. Journal of Biomedical Materials Research Part A. pp. 3514-3519. ISSN 1549-3296

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Abstract

Coaxial electrospinning technique was introduced as a flexible and promising technique for the fabrication of core-shell fibrous scaffold from poly ethylene glycol/poly caprolactone (PEG/PCL), where retinal pigmented epithelium-derived factor (PEDF) was encapsulated in the core, for photoreceptor differentiation of conjunctiva mesenchymal stem cells (CJMSCs) seed on scaffolds. The morphology and structure of fibers were characterized using SEM and TEM and photoreceptor differentiation was examined by quantitative real time PCR (qPCR). Release study showed that, a sustained release of PEDF from PEG/PCL scaffold was observed over 14 days. qPCR analysis demonstrated that rhodopsin (as a main photoreceptor gene) was significantly expressed in CJMSCs cultured on scaffold loaded with PEDF. According to the result, the core-shell scaffold loaded with PEDF (PEG+PEDF)/PCL) has superior control over factor release profile and has a potential for guiding photoreceptor differentiation of mesenchymal stem cells and promoting retinal regeneration. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3514-3519, 2017.

Item Type: Article
Keywords: coaxial electrospinning core-shell fibrous scaffold control release PEDF photoreceptor-like cell GROWTH-FACTOR DELIVERY DRUG-DELIVERY STROMAL CELLS TISSUE TRANSPLANTATION MEMBRANE SYSTEMS PROTEIN FIBERS EYE Engineering, Biomedical Materials Science, Biomaterials
Page Range: pp. 3514-3519
Journal or Publication Title: Journal of Biomedical Materials Research Part A
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 105
Number: 12
Identification Number: https://doi.org/10.1002/jbm.a.36182 <Go to ISI>://WOS:000413918800028
ISSN: 1549-3296
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/25

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