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Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives

(2015) Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH. pp. 417-424.

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Abstract

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds I-a, I-b, I-B and II16 exhibited the highest antiplatelet aggregation activity (36.75, 72.4, 62.5 and 80 mu M). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2-aminopyrimidines were more active than 4,6-diaminopyrimidines in this respect.

Item Type: Article
Keywords: 2-aminopyrimidines; 2-Substituted-4,6-diaminopyrimidines; Antiplatelet aggregation
Page Range: pp. 417-424
Journal or Publication Title: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 14
Number: 2
Publisher: web of science,pubmed
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2462

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