Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels

(2015) Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. pp. 326-335.

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Delivery of the hydrophilic drugs to the brain is still a great challenge for the treatment of many CNS-related diseases. Nanogels loaded by methotrexate (MIX) were prepared using the ionic gelation method. After intravenous administration of surface-modified (SMNs) and unmodified nanogels (UMNs) compared to the free drug, the neuropharmacokinetic evaluations were applied mainly by tissue drug uptake and graphic estimation of the uptake clearance methods. In optimized condition, the particle sizes of UMNs and SMNs were 118.54 +/- 15.93 nm and 106.68 +/- 7.23 nm, respectively. Drug entrapment efficiency and drug loading capacity were 61.82 +/- 6.84%, and 53.68 +/- 3.09%, respectively. The brain concentrations of MTX were shown to be higher in the case of both types of the nanogels. There were no significant differences between SMNs and UMNs in terms of the brain concentrations and AUCs of brain concentration-time profiles. Meanwhile, the brain uptake clearance of the drug loaded in SMNs were significantly higher than UMN ones (i.e. about 3- and 1.6-times for the high and low MIX doses, respectively). It can be concluded that, while the drug loading in both forms of nanogels have a significant increasing effect on the brain penetration of MIX, surface treatment of nanogels exerts an additional effect on the plasma volume cleared from MTX via brain tissue in time unit. (c) 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Hydrogel nanoparticles; Methotrexate; Surface modification; Blood-brain barrier; Uptake clearance
Page Range: pp. 326-335
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 79
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی

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