Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Design, Synthesis and Cytotoxicity Evaluationof New 1,2-diaryl-4, 5, 6, 7-Tetrahydro-1H-benzod] Imidazolesas Tubulin Inhibitors

(2015) Design, Synthesis and Cytotoxicity Evaluationof New 1,2-diaryl-4, 5, 6, 7-Tetrahydro-1H-benzod] Imidazolesas Tubulin Inhibitors. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH. pp. 59-65.

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Abstract

A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzod]imidazoles, possessing trimethoxyphenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithelial cells), T47D (Human ductal breast epithelial tumor cell line) and fibroblast. According to our results, HEPG2 seems to be the most sensitive, while MCF7 was the most resistant cell line to the compounds. All the compounds expect 7b, possessed satisfactory activity against HEPG2 with mean IC50 values ranging from 15.60 to 43.81 mu M.

Item Type: Article
Keywords: 4,5,6,7-Tetrahydro-1H-benzod]imidazole; Antitubulin; Molecular modeling; Cytotoxicity
Page Range: pp. 59-65
Journal or Publication Title: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 14
Number: 1
Publisher: web of science
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2422

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