Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Solubility of Naproxen in Polyethylene Glycol 200+Water Mixtures at Various Temperatures

(2015) Solubility of Naproxen in Polyethylene Glycol 200+Water Mixtures at Various Temperatures. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH. pp. 1041-1050.

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Abstract

The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van't Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van't Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. The obtained solubility calculation errors vary from similar to 17 % up to 35 % depend on the number of required input data. Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban-Acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems.

Item Type: Article
Keywords: Thermodynamic analysis; Solubility; Naproxen; Jouyban-acree model
Page Range: pp. 1041-1050
Journal or Publication Title: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 14
Number: 4
Publisher: web of science
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2322

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