Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Toxic effects of magnesium oxide nanopartides on early developmental and larval stages of zebrafish (Danio rerio)

(2015) Toxic effects of magnesium oxide nanopartides on early developmental and larval stages of zebrafish (Danio rerio). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. pp. 260-267.

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Abstract

Magnesium oxide nanoparticles (MgONPs) are used in medicine, manufacturing and food industries. Because of their extensive application in our daily lives, environmental exposure to these nanoparticles is inevitable. The present study examined the effects of MgONPs on zebrafish (Danio rerio) early developmental stages. The results showed that, at different concentrations, MgONPs induced cellular apoptosis and intracellular reactive oxygen species. The hatching rate and survival of embryos decreased in a dose dependent manner. The 96-h LC50 value of MgONPs on zebrafish survival was 428 mg/l and the 48-h EC50 value of MgONPs on zebrafish embryo hatching rate was 175 mg/l. Moreover different types of malformation were observed in exposed embryos. The results demonstrate the toxic effects of MgONPs on zebrafish embryos and emphasize the need for further studies. (C) 2015 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Zebrafish; Fish embryos; Toxicity; Malformation; MgO nanoparticles
Page Range: pp. 260-267
Journal or Publication Title: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Abstract and Indexing: ISI, Pubmed
Quartile : Q1
Volume: 122
Publisher: web of science
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2224

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