Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population

(2015) Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population. BLOOD COAGULATION & FIBRINOLYSIS. pp. 869-873.

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Abstract

There are limited data on the role of methylenetetrahydrofolate reductase C677T polymorphism and hyperhomocysteinemia as risk factors for cerebral venous thrombosis in Iranian population. We examined a possible association between fasting plasma homocysteine levels, methylenetetrahydrofolate reductase C677T polymorphism, and cerebral venous thrombosis in 50 patients with a diagnosis of cerebral venous thrombosis (20-63 years old) and 75 healthy controls (18-65 years old). Genotyping of the methylenetetrahydrofolate reductase C677T gene polymorphism was performed by PCR-restriction fragment length polymorphism analysis, and homocysteine levels were measured by enzyme immunoassay. Fasting plasma homocysteine levels were significantly higher in cerebral venous thrombosis patients than in controls (P=0.015). Moreover, plasma homocysteine levels were significantly higher in methylenetetrahydrofolate reductase 677TT genotype compared to 677CT and 677CC genotypes in both cerebral venous thrombosis patients (P=0.01) and controls (P=0.03). Neither 677CT heterozygote genotype odds ratio (OR) 1.35, 95% confidence interval (CI) 0.64-2.84, P=0.556] nor 677TT homozygote genotype (OR 1.73, 95% CI 0.32-9.21, P=0.833) was significantly associated with cerebral venous thrombosis. Additionally, no significant differences in the frequency of 677T allele between cerebral venous thrombosis patients and controls were identified (OR 1.31, 95% CI 0.69-2.50, P=0.512). In conclusion, our study demonstrated that elevated plasma homocysteine levels are significant risk factors for cerebral venous thrombosis. Also, methylenetetrahydrofolate reductase 677TT genotype is not linked with cerebral venous thrombosis, but is a determinant of elevated plasma homocysteine levels. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Keywords: cerebral venous thrombosis; homocysteine; methylenetetrahydrofolate reductase; PCR; polymorphism; restriction fragment length polymorphism
Page Range: pp. 869-873
Journal or Publication Title: BLOOD COAGULATION & FIBRINOLYSIS
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 26
Number: 8
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/2223

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