Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia

(2017) Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia. Artificial Cells Nanomedicine and Biotechnology. pp. 1379-1387. ISSN 2169-1401

Full text not available from this repository. (Request a copy)

Official URL: http://apps.webofknowledge.com/full_record.do?prod...

Abstract

The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution. It was concluded that employing ion pairing agent could enhance drug encapsulation into NLCs structure.

Item Type: Article
Keywords: Arginine alopecia nanostructured lipid carriers dermal drug delivery NLC IN-VITRO 5-ALPHA-REDUCTASE INHIBITORS SKIN PENETRATION DERMAL DELIVERY HAMSTER FLANK NANOPARTICLES PERMEATION FORMULATIONS NIOSOMES BEHAVIOR Biotechnology & Applied Microbiology Engineering, Biomedical Materials Science, Biomaterials
Page Range: pp. 1379-1387
Journal or Publication Title: Artificial Cells Nanomedicine and Biotechnology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 45
Number: 7
Identification Number: https://doi.org/10.1080/21691401.2016.1241794 <Go to ISI>://WOS:000413975300016
ISSN: 2169-1401
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/208

Actions (login required)

View Item View Item