Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Moderate O-3/O-2 therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss

(2017) Moderate O-3/O-2 therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss. Free Radical Research. pp. 828-837. ISSN 1071-5762

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Abstract

Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss (NIHL). In this study, we examined the protective effect of O-2/O-3 mixture (ozone/oxygen) therapy against mitochondrial induced damage and oxidative stress by noise exposure in rat brain and cochlear. For this purpose, rats were divided into four groups: 1 - control group; 2 - noise-exposed group (100dB); 3 - noise+O-2/O-3, and 4 - O-2/O-3 (30 mu g/ml). After 14 d, animals were anesthetised. Rat brain and cochlear tissue were removed for evaluation of the histopathological damages, oxidative stress, and mitochondrial dysfunction in both tissues. Our findings indicated that noise caused pathological damage, oxidative stress, and mitochondrial dysfunction in rat brain and cochlear. Also, daily administration of an O-2/O-3 therapy (30 mu g/ml intravenous) efficiently increased enzymatic and non-enzymatic antioxidant in brain and cochlear that this action led to inhibition of pathological damages, oxidative stress, reactive oxygen species formation, mitochondrial membrane potential (MMP) collapse, mitochondrial swelling, and cytochrome c release resulting from noise. These findings suggest that the moderate O-2/O-3 therapy enhances the capacity of enzymatic and non-enzymatic antioxidant in brain and cochlear that protects against NIHL.

Item Type: Article
Keywords: Ozone/oxygen therapy oxidative stress mitochondria noise hearing loss CYTOCHROME-C RELEASE OXIDATIVE STRESS RAT-BRAIN TOXICITY MITOCHONDRIA LYMPHOCYTES PREVENTION INDUCTION Biochemistry & Molecular Biology
Page Range: pp. 828-837
Journal or Publication Title: Free Radical Research
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 51
Number: 9-10
Identification Number: https://doi.org/10.1080/10715762.2017.1381695 <Go to ISI>://WOS:000415660400007
ISSN: 1071-5762
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/205

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