Abstract

Objective: To assess the effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Methods: In a double-blinded, placebo-controlled clinical trial, 70 type 2 diabetic patients were enrolled. They allocated randomly into ginger group and control group. They consumed 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks. Serum sugar, lipids, CRP, PGE2 and TNF alpha were measured before and after intervention. Results: Ginger reduced fasting plasma glucose, HbA(1C), insulin, HOMA, triglyceride, total cholesterol, CRP and PGE(2) significantly compared with placebo group (p<0.05). There were no significant differences in HDL, LDL and TNF alpha between two groups (p>0.05). Conclusion: Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE(2) in type 2 diabetic patients. Therefore ginger can be considered as an effective treatment for prevention of diabetes complications.