Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Solubility data of diazepam in binary and ternary mixtures of PEGs 200 and 400 with N-methyl pyrrolidone and water at 298.2 K: Experimental data and modeling

(2013) Solubility data of diazepam in binary and ternary mixtures of PEGs 200 and 400 with N-methyl pyrrolidone and water at 298.2 K: Experimental data and modeling. Journal of Solution Chemistry. pp. 2281-2295.

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Abstract

Experimental solubilities of diazepam in binary and ternary solvents of polyethylene glycols 200 and 400 with N-methyl pyrrolidone and water at T = 298.2 K are reported. The Jouyban-Acree model was used to fit solubility data of diazepam in the binary and ternary solvent mixtures (106 data points) in which the overall mean relative deviations (OMRD %) is 13.1 % and the prediction OMRD % is 31.7 %. The combined version of the Jouyban-Acree model with Hansen solubility parameters was used for fitting and predicting the solubility data and the OMRDs % are 10.0 and 20.8 %, respectively. Also, the previously proposed trained versions of the Jouyban-Acree model were used for predicting the reported data in this work and all results are listed in the tables. The density of the solute-free solvent mixtures were measured and employed to calculate the constants of the Jouyban-Acree model and then the densities of the saturated solutions were predicted.

Item Type: Article
Keywords: Author Keywords:Diazepam; Solubility; PEG 200 and 400; NMP; Modeling KeyWords Plus:JOUYBAN-ACREE MODEL; ETHANOL PLUS WATER; DRUG SOLUBILITY; MATHEMATICAL REPRESENTATION; PREDICTION; ACETAMINOPHEN; IBUPROFEN; DENSITY; IMPROVE
Page Range: pp. 2281-2295
Journal or Publication Title: Journal of Solution Chemistry
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 42
Number: 12
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1935

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