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Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Solubility of lamotrigine in binary and ternary mixtures of pegs 200, 400, and 600 with ethanol, pg, and water at 298.2 k

(2013) Solubility of lamotrigine in binary and ternary mixtures of pegs 200, 400, and 600 with ethanol, pg, and water at 298.2 k. Chemical Engineering Communications. pp. 1443-1456.

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Abstract

Experimental solubilities of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (lamotrigine) in binary and ternary solvents of polyethylene glycols (PEGs) 200, 400, and 600 with ethanol and water, and PEGs 200, 400, and 600 with propylene glycol (PG) and water at T=298.2K are reported. The Jouyban-Acree model was used to fit solubility data of lamotrigine in the binary and ternary solvent mixtures (145 data points) in which the overall mean relative deviation (OMRD %) was 11.5%. The density of the solute-free solvent mixtures was measured and employed to calculate the constants of the Jouyban-Acree model and then the density of the saturated solutions is predicted.

Item Type: Article
Keywords: Author Keywords:Density; Jouyban-acree model; Lamotrigine; Modeling; Solubility; Solvent mixture KeyWords Plus:JOUYBAN-ACREE MODEL; DRUG SOLUBILITY; MATHEMATICAL REPRESENTATION; COSOLVENT MIXTURES; PREDICTION; TEMPERATURES
Page Range: pp. 1443-1456
Journal or Publication Title: Chemical Engineering Communications
Abstract and Indexing: ISI, Scopus
Quartile : Q2
Volume: 200
Number: 11
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1934

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