Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

A Pharmacokinetic Overview of Nanotechnology-Based Drug Delivery Systems: An ADME-Oriented Approach

(2013) A Pharmacokinetic Overview of Nanotechnology-Based Drug Delivery Systems: An ADME-Oriented Approach. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS. pp. 435-467.

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Abstract

With the extensive progress in nanotechnology-based drug delivery systems, pharmacokinetic evaluations have gained much attention from researchers as a central part of the study of these systems. Because the fulfillment of any therapeutic goal(s) by a novel drug delivery system requires that the absorption, distribution, metabolism, and excretion (ADME) be considered from the early stages of the system design to the final clinical evaluations, extensive knowledge of the pharmacokinetic aspects related to ADME is a crucial part of research in this field. The main objectives of the nanotechnology-based drug delivery systems from a pharmacokinetic viewpoint are (1) an improved drug-release profile in vivo, (2) enhanced drug absorption, (3) site-directed drug distribution, (4) a modified drug metabolism pattern, (5) prolonged drug residence time in body (e.g., in blood circulation), and (6) delayed and/or decreased renal excretion of the drug. Accordingly, the purpose of the current review is to present an insightful summary of pharmacokinetic analyses of nanotechnology-based drug delivery systems along with a critical review of recent findings.

Item Type: Article
Keywords: Author Keywords:nanotechnology; nanocarriers; drug delivery; pharmacokinetic KeyWords Plus:SOLID LIPID NANOPARTICLES; BLOOD-BRAIN-BARRIER; INTRAVENOUSLY INJECTED MICROSPHERES; IN-VIVO EVALUATION; PARTICLE-SIZE; QUANTUM DOTS; POLYMERIC NANOPARTICLES; BIODISTRIBUTION CHARACTERISTICS; POLYSTYRENE MICROSPHERES; STEALTH NANOPARTICLES
Page Range: pp. 435-467
Journal or Publication Title: CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 30
Number: 5
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1822

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