Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

The Anticancer Agent Prodigiosin Is Not a Multidrug Resistance Protein Substrate

(2013) The Anticancer Agent Prodigiosin Is Not a Multidrug Resistance Protein Substrate. DNA AND CELL BIOLOGY. pp. 90-97.

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Abstract

The brilliant red pigments prodiginines are natural secondary metabolites that are produced by select species of Gram-negative and Gram-positive bacteria. These molecules have received significant attention due to their reported antibacterial, antifungal, immunosuppressive, and anticancer activities. In this study, a Serratia marcescens SER1 strain was isolated and verified using 16s rDNA. The prodigiosin was purified using silica chromatography and was analyzed by H-1-NMR spectroscopy. The cell cytotoxic effects of the purified prodigiosin on multiple drug resistant cell lines that overexpress MDR1, BCRP, or MRP2 pumps were analyzed. Prodigiosin had nearly identical cytotoxic effects on the resistant cells in comparison to their parental lines. In agreement with the same prodigiosin cytotoxicity, FACS analysis of prodigiosin accumulation and efflux in MDR over-expressing cell lines also indicated that this pro-apoptotic agent operates independently of the presence of the MDR1, BCRP, or MRP transporter and may be a potential treatment for malignant cancer cells that overexpress multidrug resistance transporters.

Item Type: Article
Keywords: KeyWords Plus:CANCER-CELL-LINES; BACTERIAL PRODIGININES; DRUG-RESISTANCE; SERRATIA; APOPTOSIS; BCRP; RED; BIOSYNTHESIS; MECHANISMS; EXPRESSION
Page Range: pp. 90-97
Journal or Publication Title: DNA AND CELL BIOLOGY
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 32
Number: 3
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1785

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