Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

(2013) Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy. Epilepsia. e9-e12.

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Abstract

Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of ?-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetani

Item Type: Article
Keywords: Author Keywords:Bumetanide; Temporal lobe epilepsy; NKCC1; GABA KeyWords Plus:GABA
Page Range: e9-e12
Journal or Publication Title: Epilepsia
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 54
Number: 1
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1783

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