Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology

(2013) Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology. Archives of Gynecology and Obstetrics. pp. 1017-1021.

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Abstract

The incidence of poor ovarian response in controlled ovarian stimulation (COH) has been reported in 9-24 % of IVF-ET cycles. Growth hormone augments the effect of gonadotropin on granulosa and theca cells, and plays an essential role in ovarian function, including follicular development, estrogen synthesis and oocyte maturation. The aim of this study was to assess IVF-ET cycle outcome after the addition of growth hormone in antagonist protocol in poor responders. Eighty-two poor responder patients selected for ART enrolled the study and were randomly divided into two groups. Group I (GH/HMG/GnRHant group, n = 40) received growth hormone/gonadotropin/GnRH antagonist protocol and group II (HMG/GnRHant group, n = 42) received gonadotropin/GnRH antagonist protocol. The number of retrieved oocytes was significantly higher in GH/HMG/GnRHant group than HMG/GnRHant group, 6.10 +/- A 2.90 vs. 4.80 +/- A 2.40 (p = 0.035) and the number of obtained embryos was also significantly higher in GH/HMG/GnRHant group than HMG/GnRHant group, 3.7 +/- A 2.89 as compared to 2.7 +/- A 1.29 (p = 0.018). There were no significant differences between groups regarding implantation, and chemical and clinical pregnancy rates. Our study showed that co-treatment with growth hormone in antagonist protocol in patients with a history of poor response in previous IVF-ET cycles did not increase pregnancy rates.

Item Type: Article
Keywords: Author Keywords:Assisted reproductive technology; Poor responder; Growth hormone; Antagonist protocol KeyWords Plus:IN-VITRO FERTILIZATION; OVARIAN STIMULATION; FOLLICULAR DEVELOPMENT; IVF TREATMENT; METAANALYSIS; PREGNANCY; DHEA
Page Range: pp. 1017-1021
Journal or Publication Title: Archives of Gynecology and Obstetrics
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 287
Number: 5
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1779

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