Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Methotrexate-loaded chitosan nanogels as 'Trojan Horses' for drug delivery to brain: Preparation and in vitro/in vivo characterization

(2013) Methotrexate-loaded chitosan nanogels as 'Trojan Horses' for drug delivery to brain: Preparation and in vitro/in vivo characterization. International Journal of Biological Macromolecules. pp. 523-530.

Full text not available from this repository. (Request a copy)

Official URL: http://apps.webofknowledge.com/full_record.do?prod...

Abstract

Methotrexate-loaded hydrogel nanoparticles were prepared and after in vitro characterization, their transport across blood-brain barrier was investigated in vivo in intact animals in this study. The ionic gelation method was used for preparation of drug-loaded nanogels, after optimized by a systematic multi-objective optimization approach. After surface-modification with polysorbate 80, nanoparticles with the final particle size, poly-dispersity index (PDI), loading efficiency (LE) and loading capacity (LC) of 118.54 +/- 15.93 nm, 0.35 +/- 0.05, 61.82 +/- 6.84%, and 53.68 +/- 3.09% were obtained, respectively. The in vitro drug release study indicated non-Fickian diffusion kinetic, apparently governed by both diffusion of the drug out of the nanoparticles and swelling/disintegration of the polymeric network as characterized by a Weibull model for both surface-treated and untreated nanogels. After intravenous administration of surface-modified and unmodified nanogels compared to the free drug, all with the same dose of 25 mg/kg, remarkably higher brain concentrations of methotrexate were achieved with the nanogel formulations in comparison to the free drug (in some cases, more than 10-fold); but there were no significant differences between the surface-modified and unmodified nanogels in all the time points tested. (C) 2013 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Author Keywords:Methotrexate; Nanogel; Brain drug delivery; Surface modification; Release kinetic; Blood-brain barrier KeyWords Plus:NANOPARTICLES; RELEASE; MECHANISMS; TRANSPORT; CARRIER; OPTIMIZATION; SYSTEMS; SURFACE; CNS
Page Range: pp. 523-530
Journal or Publication Title: International Journal of Biological Macromolecules
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 62
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1745

Actions (login required)

View Item View Item