Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study

(2012) Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study. BIOPHARMACEUTICS & DRUG DISPOSITION. pp. 324-331.

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Omeprazole is metabolized in the liver mainly by the polymorphic CYP2C19 enzyme. Considerable ethnic differences have been reported in the pharmacokinetics of omeprazole. The present study was conducted to evaluate the pharmacokinetic parameters of omeprazole after a single oral administration to a random Iranian population. Thirty healthy male subjects, aged 2431?years, weighing 6098?kg completed the study. Plasma concentrations of omeprazole were measured over a 12?h period after administration of a single oral dose of 20?mg omeprazole. The pharmacokinetic parameters were calculated from the plasma concentrationtime profiles. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was used to quantify 5-hydroxyomeprazole. The mean area under the concentrationtime curve (AUC) from time zero to infinity (AUC8) values of omeprazole and the corresponding coefficient of variation (CV%) was 987.3?ng?h/ml (65%). In general, most subjects showed a normal distribution. Only one subject showed a very high AUC compared with the corresponding mean AUC level. This subject had the highest half-life and the lowest rate of elimination. The omeprazole metabolic ratio for this subject was 2.9, while for the others it was in the range 0.120.56. These results are consistent with previous literature that showed the existence of interindividual variability in omeprazole pharmacokinetics, even within a single ethnic group. Differences in the pharmacokinetics could be due to differences in the genetic make-up of subjects as found in their omeprazole metabolic ratios. Copyright (c) 2012 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: omeprazole; pharmacokinetic variation; Iranian subjects
Page Range: pp. 324-331
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 33
Number: 6
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی

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