Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery

(2012) Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery. CARBOHYDRATE POLYMERS. pp. 462-471.

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Abstract

Nanogels loaded with methotrexate (MTX) were prepared via an ionic gelation process using chitosan and sodium tripolyphosphate (TPP). The preparation process was optimized by a systematic multi-objective-optimization approach in terms of the size, poly-dispersity index (PDI), loading efficiency (LE) and loading capacity (LC) of the resulting nanocarriers. A combination of the pH of the chitosan solution, the addition time of the TPP solution and temperature effects accounted for nearly 75% of the variation in nanogel size; the TPP initial concentration had a very significant effect on LE (p<0.0001). The final particle size (Z-average (rnm)), PDI, LE and LC corresponding to the optimal conditions were 59.27 nm, 0.34,61.82% and 53.68%, respectively. As the ultimate goal, the surfaces of the MTX-loaded nanogels were modified by polysorbate 80 for the purpose of brain targeting. The cumulative in vitro release profiles of surfactant-coated and uncoated nanogels were almost identical and showed acceptable performance. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Hydrogel nanoparticles; Multi-objective optimization; Surface functionalization; Chitosan; Methotrexate; Polysorbate 80
Page Range: pp. 462-471
Journal or Publication Title: CARBOHYDRATE POLYMERS
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 90
Number: 1
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1373

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