Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Evaluation of Novel alpha-(Acyloxy)-alpha-(Quinolin-4-yl) Acetamides as Antiplasmodial Agents

(2017) Evaluation of Novel alpha-(Acyloxy)-alpha-(Quinolin-4-yl) Acetamides as Antiplasmodial Agents. Iranian Journal of Pharmaceutical Research. pp. 924-928. ISSN 1735-0328

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Abstract

Because of expanding resistance to efficient and affordable antimalarial drugs like chloroquine, the search is continuing for more effective drugs against this disease. In-vitro antiplasmodial activity and cytotoxicity of alpha-(acyloxy)-alpha-(quinolin-4-yl) acetamides on Plasmodium falciparum and structure-activity relationships of this new class of Passerini adducts is described. The in-vitro antiplasmodial activity of compounds was tested against chloroquine sensitive 3D7 strain. Toxicity of active compounds was investigated on HepG2 cell line. Compounds 1, 20 and 22 showed significant antiplasmodial activity with IC50 value of 1.511, 1.373 and 1.325 mu M, respectively. The active compounds did not show noticeable toxicity when tested against HepG2 cell line. The present results bring essential elements which will be used for the synthesis of more active derivatives of alpha-(acyloxy)-alpha-(quinolin-4-yl) acetamides.

Item Type: Article
Keywords: Plasmodium falciparum Quinolines Cytotoxicity HepG2 3D7 strain IN-VITRO MALARIA EXTRACTS Pharmacology & Pharmacy
Page Range: pp. 924-928
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 16
Number: 3
Identification Number: <Go to ISI>://WOS:000408319400008
ISSN: 1735-0328
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/134

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