Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, southeast Iran

(2011) Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, southeast Iran. Annals of Saudi Medicine. pp. 171-173.

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BACKGROUND AND OBJECTIVES: Analysis of the role of different alleles of human leukocyte antigen (HLA) in rheumatoid arthritis (RA) patients is necessary in many populations and geographical areas. The aim of the present study was to investigate the frequency of HLA-DRB1 alleles in RA patients, comparing with that in control group in southeast Iran. DESIGN AND SETTING: Case-control study of rheumatoid arthritis patients referred to rheumatology clinic at university hospital. PATIENTS AND METHODS: The frequency of HLA-DRB1 alleles was determined in 79 RA patients and 93 healthy subjects in Zahedan, southeast Iran. HLA-DRB1 allele types were identified by polymerase chain reaction with sequence-specific primer (PCR-SSP). RESULTS: The HLA-DRB1*10 allele showed a significantly higher frequency in patients with RA (OR=2.698, 95% CI=1.087-6.699, P=.045), while the frequency of DRB1*03 allele in these subjects was significantly lower than that in the control group (OR=0.447, 95% CI=0.2285-0.8729, P=.021). The frequencies of DRB1*01, DRB1*04, DRB1*07, DRB1*09, DRB1*11, DRB1*13, DRB1*14, DRB1*15, DRB1*16 were not significantly different between RA subjects and the control group. CONCLUSION: The data suggest that the DRB1*10 allele is a risk factor and DRB1*03 is protective for RA in this population.

Item Type: Article
Page Range: pp. 171-173
Journal or Publication Title: Annals of Saudi Medicine
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 31
Number: 2
Publisher: scopus
Depositing User: خانم مریم زرقانی

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