Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: A randomized controlled trial

(2009) Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: A randomized controlled trial. Endocrine Research. pp. 80-89.

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Abstract

Objectives. To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism. Methods. Seventy-one patients diagnosed with primary hypothyroidism were randomly allocated into two study groups: the first group received usual dose of levothyroxine and the second group received combination of levothyroxine and liothyronine for at least 4 months. The main outcomes were psychosocial problems (Goldberg's General Health Questionnaire, GHQ-28), bodyweight, heart. rate, blood Pressure, and serum lipid levels. Results. In both groups serum thyroid-stimulating hormone levels remained unchanged compared with baseline. Psychosocial scores, body weight, heart rate, blood pressure, and lipid profile in the two groups remained constant. The only exception was a small but significant reduction. in anxiety/insomnia in combined treatment group as compared with monotherapy. Conclusions. The data do not support the hypothesis that combined therapy improves the well-being and general health of Patients.

Item Type: Article
Keywords: Author Keywords:Primary Hypothyroidism; Combination Therapy; Levothyroxine Monotherapy KeyWords Plus:THYROXINE PLUS TRIIODOTHYRONINE; GENERAL HEALTH QUESTIONNAIRE; QUALITY-OF-LIFE; REPLACEMENT THERAPY; CLINICAL HYPOTHYROIDISM; THYROID-HORMONE; SCALED VERSION; COMMUNITY; 3,5,3'-TRIIODOTHYRONINE; EUTHYROIDISM
Page Range: pp. 80-89
Journal or Publication Title: Endocrine Research
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 34
Number: 3
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1096

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