Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Magnetic nanogels as dual triggered anticancer drug delivery: Toxicity evaluation on isolated rat liver mitochondria

(2017) Magnetic nanogels as dual triggered anticancer drug delivery: Toxicity evaluation on isolated rat liver mitochondria. Toxicology Letters. pp. 18-29. ISSN 0378-4274

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Abstract

This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sensitive magnetic nanogels. The NPs showed outstanding entrapment efficiency for doxorubicin (76.6) with a sustained and high extent of drug release in the acidic media (pH = 5-7) compared to the neutral media. Various mitochondrial functional parameters including complex II activity, MDA amount, GSH level, membrane potential collapse, swelling, apoptosis and release of cytochrome c were used to investigate the bio-safety of the nanogels. The findings revealed that the extent of mitochondrial dysfunction of doxorubicin were in the order of free doxorubicin > doxorubicin loaded magnetic nanogels = > doxorubicin loaded Nanogels. The results also revealed that the nanogels and the magnetite nanogels seem to possess promising capability as a safe carrier in comparison of the toxic potential effect of free doxorubicin.

Item Type: Article
Keywords: Magnetic nanogels Mitochondrial dysfunction Drug delivery Bio-safety MTT assay Mitochondrial membrane potential (MMP) collapse VACCINE DELIVERY OXIDATIVE STRESS GENE DELIVERY IN-VITRO CHITOSAN NANOPARTICLES COPOLYMER CARRIERS GEMCITABINE DOXORUBICIN Toxicology
Page Range: pp. 18-29
Journal or Publication Title: Toxicology Letters
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 278
Identification Number: https://doi.org/10.1016/j.toxlet.2017.06.004 <Go to ISI>://WOS:000407566100003
ISSN: 0378-4274
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/109

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