Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effects of ginger on spermatogenesis in streptozotocin-induced diabetic rat

(2009) Effects of ginger on spermatogenesis in streptozotocin-induced diabetic rat. Journal of Medicinal Plants. pp. 118-124.

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Official URL: https://www.scopus.com/record/display.uri?eid=2-s2...

Abstract

Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10; STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively; however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results:TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in AC and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat.

Item Type: Article
Keywords: Testis | Spermatozoa | male reproductive
Page Range: pp. 118-124
Journal or Publication Title: Journal of Medicinal Plants
Abstract and Indexing: Scopus
Volume: 8
Number: 31
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1082

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