Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Brain drug targeting: a computational approach for overcoming blood-brain barrier

(2009) Brain drug targeting: a computational approach for overcoming blood-brain barrier. Drug Discovery Today. pp. 1030-1036.

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Abstract

The treatment of brain disorders is limited by the insufficiency in delivering therapeutic drugs into brain relating to highly limited transport of compounds through blood-brain barrier (BBB). Therefore, a lot of attempts have been made to rise above this problem using a variety of approaches. In this way, in silico techniques try to predict the brain permeability based on a range of physicochemical descriptors resulting from structures of the corresponding compounds. Most of the models have some disadvantages, which preclude making conclusive decision. The major defect is ignoring the main parts of process of permeability using only total concentrations for modeling. Moreover, the role of transporters is underestimated in addition to neglecting the complex nature of BBB, which, collectively, leads to uncertain results.

Item Type: Article
Keywords: KeyWords Plus:CENTRAL-NERVOUS-SYSTEM; IN-SILICO PREDICTION; CELL-PENETRATING PEPTIDES; CHOLINE TRANSPORTER; SURFACE-AREA; LARGE SET; PERMEABILITY; DELIVERY; PERMEATION; DESIGN
Page Range: pp. 1030-1036
Journal or Publication Title: Drug Discovery Today
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 14
Number: 21-22
Publisher: scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/1069

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