Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway

(2017) A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway. Journal of Cellular Biochemistry. pp. 2909-2920. ISSN 0730-2312

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Abstract

Numerous studies have demonstrated the role of A3 adenosine receptor (A3AR) and signaling pathways in the multiple aspects of the tumor. However, there is a little study about the function of A3AR in the biological processes of cancer stem cells (CSCs). CSCs have a critical role in the maintenance and survival of breast cancer. The aim of current study was to investigate the effect of A3AR agonist on breast cancer stem cells (BCSCs). XTT assay showed antiproliferative effect of A3AR agonist (Cl-IB-MECA) on BCSCs. Our results also demonstrated that A3AR agonist reduces mammosphere formation in a dose-dependent manner. Flow cytometry analysis showed that A3AR agonist induces G1 cell cycle arrest and apoptosis in BCSCs. Western blot assay showed that A3AR agonist inhibits the expression of cell cycle and apoptotic regulatory proteins as well as the expression of ERK1/2 and GLI-1 proteins. Finally, these findings propose that A3AR agonist induces cell cycle arrest and apoptosis in BCSCs by inhibition of ERK1/2 and GLI-1 cascade. (C) 2017 Wiley Periodicals, Inc.

Item Type: Article
Keywords: BREAST CANCER STEM CELLS A3 ADENOSINE RECEPTOR GLI-1 ERK1/2 CL-IB-MECA CYCLE ARREST SONIC HEDGEHOG KINASE-A APOPTOSIS LINES PROLIFERATION PHOSPHORYLATION TUMORIGENICITY METASTASIS Biochemistry & Molecular Biology Cell Biology
Page Range: pp. 2909-2920
Journal or Publication Title: Journal of Cellular Biochemistry
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 118
Number: 9
Identification Number: https://doi.org/10.1002/jcb.25945 <Go to ISI>://WOS:000405515000042
ISSN: 0730-2312
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/106

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