Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program

(2017) Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program. Journal of Pediatric Endocrinology & Metabolism. pp. 973-978. ISSN 0334-018X

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Abstract

Background: The proportion of newborns recalled during neonatal screening programs for congenital hypothyroidism (CH) varies substantially by country and may be higher in settings where povodine iodine (PVP-I) is used during delivery. We assessed this hypothesis by substituting PVP-I for chlorhexidine (CHL) and evaluated the reduction in the recall rate of the Irainian newborn screening program. Methods: This study investigated 2282 neonates of mothers admitted to a local hospital for delivery between December 2012 and October 2013. We measured thyorid stimulating hormone (TSH) levels in heel-prick blood specimens of infants, aged between 3 and 5 days, born to mothers who received PVP-I (phase I) and those who received CHL after withdrawal of PVP-I from obstetric procedures (phase II). Then we compared the median TSH levels and the recall rate based on a TSH level >= 5 mU/L. Results: Of 2282 cases, 1094 infants were born to mothers exposed to PVP-I during phase I (PVP-I group) and 1188 ones were born to mothers exposed to chlorhexidine in phase II (CHL group); 6.56 of the PVP-I group and 1.91 of the CHL group were recalled later during screening (p < 0.001). The median TSH level was significantly higher in the PVP-I group compared to the CHL group (1.35 vs. 1.00, p < 0.001). Conclusions: Replacement of iodine-containing antiseptics by iodine-free ones, during delivery resulted in a significant reduction in the recall rate of the Iranian screening program for CH.

Item Type: Article
Keywords: congenital hypothyroidism endocrinology-pediatric iodine thyroid function HAZARD Endocrinology & Metabolism Pediatrics
Page Range: pp. 973-978
Journal or Publication Title: Journal of Pediatric Endocrinology & Metabolism
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 30
Number: 9
Identification Number: https://doi.org/10.1515/jpem-2016-0164 <Go to ISI>://WOS:000408795400009
ISSN: 0334-018X
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/101

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